Abstract
The contraction of skeletal muscle requires the rapid influx of calcium into the cytosol. Ryanodine receptors (RyRs) are huge ion channels in the sarcoplasmic reticulum membrane that release Ca2+ into the cytosol upon membrane depolarization. Mutations in RyR1 cause neuromuscular diseases, such as central core disease, muscular dystrophy, and malignant hyperthermia (MH). When patients with MH undergo surgery, volatile anesthetics can trigger a dangerous rise in body temperature and ultimately death.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
