Abstract
The contraction of skeletal muscle requires the rapid influx of calcium into the cytosol. Ryanodine receptors (RyRs) are huge ion channels in the sarcoplasmic reticulum membrane that release Ca2+ into the cytosol upon membrane depolarization. Mutations in RyR1 cause neuromuscular diseases, such as central core disease, muscular dystrophy, and malignant hyperthermia (MH). When patients with MH undergo surgery, volatile anesthetics can trigger a dangerous rise in body temperature and ultimately death.
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