Abstract
Development and in vitro characterization of metronidazole loaded chitosan microspheres for delivery to periodontal pocketPreeti K. Suresh, Mahendra Kumar Dewangan
Highlights
Metoprolol Succinate (MS) is a β 1-selective adrenergic blocking agent (Sandberg et al, 1998)
The data obtained from the study suggests that Crushed Puffed Rice (CPR) in combination with High Molecular Weight Chitosan (HMWCH) or HPMC K15 or HPMC K15 + HMWCH has sufficient potential to be used as a carrier for stomach specific drug delivery
Derivative Thermo Gravimetric Analysis (DTG) and TG thermogram represent the biopolymer are stable up to the temperature of 290 0C, exothermic peak at 633 0C represents the degradation of biopolymer and maximum loss of mass 41.6% occurs from temperature 253 0C to 316 0C and 4.7% loss of mass occurs at temperature 639 0C
Summary
Average floating time for the formulation is 08 hours. CPR is used as a buoyancy imparting agent due to its floating behavior; it floats in 0.1 M HCl (pH 1.2) and remained unwetted for the time period of 05 hours. CPR, HPMC K15, and HMWCH have a significant effect (p < 0.05) on MS retarding. Formulation D1-D9 follows zero order model and Fickian diffusion which was confirmed by R2 value and Akaike Information Criteria (AIC)
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