Cruroplasty with or without mesh? A systematic literature review with a novel time-organized proportion meta-analysis.

Abstract

Improved outcomes with the use of non-absorbable mesh (NAM) for inguinal hernia repairs led to its rapid adoption for hiatal hernia (HH) repairs; however, feared complications occurred, and the trend shifted toward using absorbable mesh (AM). We aimed to analyze the literature assessing objective HH recurrence rates after primary laparoscopic cruroplasty with or without the use of different mesh types. A systematic literature review with both pairwise and time-organized proportion meta-analyses of articles published between January 1993 and September 2022 was performed using the MEDLINE, EMBASE, and Taylor & Francis databases to identify relevant studies comparing groups undergoing cruroplasty with suture repair (SR) alone, AM, NAM, or partially absorbable mesh (PAM). Studies documenting an objective follow-up ≥ 6months were included. The primary outcome was the HH recurrence rate confirmed by barium esophagram or upper GI endoscopy. A total of 34 studies met the inclusion criteria, including 6 randomized clinical trials, 25 retrospectives studies, and 3 prospective cohort studies. A total of 2170 subjects underwent laparoscopic HH repair and completed an objective follow-up ≥ 6months after surgery; the objective recurrence rate was 20.8% (99/477) at a mean follow-up of 25.8 ± 16.4months for the SR group, 20.6% (244/1187) at 28.1 ± 13.8months for the AM group, 13.7% (65/475) at 30.8 ± 15.3months for the NAM group, and 0% (0/31) at 32.5 ± 13.5months for the PAM group. However, thepairwise meta-analysis revealed that overall mesh use was not superior to SR in preventing long-term HH recurrence. The use of AM does not appear to reduce HH recurrence compared to SR alone. Although the data favors NAM to decrease objective HH recurrence in the mid-term, the long-term (≥ 48months) recurrence rate was similar with or without any type of mesh.