Abstract
Crumbs and Xpd in mitosis.
Highlights
Crb is a conserved cell membrane protein essential for cell polarity
This suggests that the CGX function is required for cell proliferation in disc epithelia, in addition to its role in chromosome segregation in embryo
Hyper-proliferation of wing disc by Crbintra is accompanied by a concomitant increase in DNA damage response to double stranded DNA breaks (DSB) indicated by histone H2Av phosphorylation
Summary
Crb is a conserved cell membrane protein essential for cell polarity. An unexpected linkage between Crb and mitosis was made through a finding of galla-1 RNAi as a suppressor of the eye phenotype caused by Crb overexpression. As expected from the MIP18-XPD interaction in human cells, Galla physically interacts with Xpd. In addition, Galla and Xpd associate with Crb to form a new Crb-Galla-Xpd (CGX) complex. Galla-2 may be more critical than Galla-1 in forming the CGX complex. It is possible that Crb and Galla-1 may form a distinct complex with another Xpd-like protein.
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