Abstract
Terminalia chebula is an ancient medicinal herb. it is also known as Haritaki, Yellow myrobalan, Chebulic myrobalan, Yellow myrobalan, and Terminalia chebulabe longs to Combretaceae family is a major Ayurvedic medicine that is native to South Asia, predominantly from India. Apart from Ayurveda, it is commonly used in Unani and Homeopathic medicine systems. Because of the broad variety of pharmacological activities connected with the biologically active constitutents found throughout this herb, it is included in conventional medicine. The fruit contains main pharmacological activities such as Hepatoprotective activity, Cytoprotective activity Cardioprotective activity, Antidiabetic and renoprotective activity, Antibacterial activity, Antifungal activity, Antiviral activity, Antiprotozoal activity, Anti-inflammatory and anti-arthritic activity, antioxidant and free radical scavenging activity, Anticarcinogenic activity, Antimutagenic, radioprotective and Chemopreventive activity, Hypolipidemic and hypocholesterolemic activity, Adaptogenic and anti anaphylactic activities, Gastrointestinal motility improving and anti-ulcerogenic activity, Antispasmodic activity, Wound healing activity, Anticaries activity, Immunomodulatory activity any many are reported with scientific evidence. All these ancient applications of Terminalia chebula as home remedies have been confirmed in preclinical trials. The current evidence on the effect of Terminalia chebula intake or consumption on gastrointestinal disorders and diseases is scientifically based on preclinical and clinical trials. All these ancient applications of Terminalia chebula as home remedies have been confirmed in preclinical trials. The current evidence on the effect of Terminalia chebula intake or consumption on gastrointestinal disorders and diseases is scientifically based on preclinical and clinical trials. Study indicates different dosage of Terminalia chebula is effective to get relief from gastrointestinal troubles. Due to less number of gastrointestinal studies, there is no scientific report to consume a specific amount of dose. To prove that Terminalia chebula and its standard extracts are effective as a gastroprotective agent, more comprehensive preclinical and clinical trials are required. To reliably evaluate the appropriate dosages for specific disorders and preparation of extract of Terminalia chebula fruit in prospective human trials procedures, dose-finding preclinical studies should be conducted. There is an evident need for more patient and physician education concerning specific therapies, legislation to regulate the quality of pharmaceutical preparations, and, in particular, more clinical and pre-clinical trials to determine the value and safety of such medicaments in digestive and other disorders.
Highlights
Increase the chances of completing a clinical course the trial that culminated in the approval of a new drug, the choice of192 Volume 01 Issue 09 December 2021 suitable preclinical models is identifying a healthy, powerful one, Efficient and effective drugs require thorough use of Preclinical research, which assesses aspects of Corresponding Author: Sharmila DusiPharmacodynamics, kinetics, and pharmacokinetics
One of the most revered medicinal plants i.e Terminalia chebula belongs to the Combretaceae family, which, due to the presence of a large number of different forms of phytoconstituents, has numerous medicinal activities to exhibit therapeutic pharmacological activity
We summarize animal model evaluating the effect of Terminalia chebula ingestion in gastrointestinal disorders
Summary
Increase the chances of completing a clinical course the trial that culminated in the approval of a new drug, the choice of. Terminalia chebula is a major pharmaceutical medicinal plant and has been used since ancient times in the Unani System of Medicine, Ayurveda to fight various diseases and infections due to its potential medicinal use This herb has been considered a valuable and inexpensive source of specific phytoconstituents that are commonly used in the production of drugs with higher safety profiles and lower side effects. In pylorus ligation and ethanol-induced ulcer models in Wistar rats, the anti-ulcer function of Terminalia chebula fruit methanolic extract was investigated. Terminalia chebula extract have both antiulcerogenic and ulcer healing properties, which could have been due to their gastroprotective activity It studied the gastro-protective function of chebulinic acid derived from the fruit of Terminalia chebula. The anti-ulcer operation of a methanol extract of Terminalia chebula fruit been examined in pylorus ulcer-induced ligation and ethanol models in Wistar rats.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
