Abstract
Crucial role of the MAPKAP kinases 2 and 3 for pathogen-induced inflammation and their relevance for the immune response of the liver
Highlights
The liver plays an important role in innate and adaptive immunity and in particular in induction of tolerance
MK2 and to a lesser extent MK3 are critical for regulation of TNF-a, IL-6 and IL-10 in response to LPS, where they are involved in control of transcript stability or translation
Extended analysis of LPS-induced gene expression in macrophages derived from wild-type animals or from animals deficient for MK2 or MK2 and MK3 using “whole genome microarrays” suggested that there is a larger group of genes, which are controlled by MK2 and MK3 in a way that is comparable to that of IFN-b
Summary
The liver plays an important role in innate and adaptive immunity and in particular in induction of tolerance. MK2 and to a lesser extent MK3 are critical for regulation of TNF-a, IL-6 and IL-10 in response to LPS, where they are involved in control of transcript stability or translation.
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