Abstract
Background: Croton zambesicus Muell Arg. (Euphorbiaceace) is a medicinal plant used traditionally in the treatment of some ailments.
 Aim: The root extract of Croton zambesicus was evaluated for effect on the gastrointestinal tract (GIT).
 Materials and Methods: The root extract of C. zambesicus (27-81 mg/kg) was investigated for laxative effect in rats using different experimental models to study its effect on the GIT.
 Results: The extract was found to significantly increase the frequency and output of faecal matters in rats in all the experimental models studied.
 Conclusion: The findings of this study show that the root extract of C. zambesicus has a significant laxative effect and this supports its use in ethnomedicine for the treatment of gastrointestinal tract disorders.
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