CrossTalk proposal: Diffusion limitation of O2 from microvessels into muscle does contribute to the limitation of V̇O2 max.

Abstract

At maximal oxygen uptake () we know that (1) muscle O2 extraction is not 100%, yet (2) hyperoxia increases . The reason for (1) is diffusion limitation of O2 from the muscle microvessels to the mitochondria. This does not exclude ‘central’ factors from also affecting , as will be explained.