Abstract
Suppose you want to take a car for a test drive. You prefer a smooth ride, so you are probably particularly interested in the car’s suspension system. Where do you take your car? Will you take it for a ride on a well-maintained highway, or will you select worn-down roads with cobblestones, potholes and speed bumps? The answer is clear: you can’t test the car’s suspension system if you don’t challenge it. Now imagine cerebral autoregulation (CA) as our brain’s suspension system, dampening out fluctuations in blood flow as blood pressure varies.
Highlights
David Simpson, after schooling in Austria, graduated in Biomedical Electronics from the University of Salford (1981) and worked as a mathematics and physics teacher in Nigeria
As indicated in the introduction, their larger perturbations in arterial blood pressure (ABP) and cerebral blood flow (CBF) are representative of physiologically and clinically relevant everyday challenges to cerebral autoregulation (CA), where CA responses probably have a necessary protective function. These large perturbations allow us to study the CBF response to ABP with increased certainty that there is a causal relationship between ABP and CBF, which is a prerequisite to assessing CA
Can we be certain that the CA we assess using large, induced perturbations is comparable to the CA we assess with smaller, spontaneous perturbations? There is some evidence that autoregulatory responses to relatively large changes in ABP are similar to those resulting from small changes
Summary
David Simpson, after schooling in Austria, graduated in Biomedical Electronics from the University of Salford (1981) and worked as a mathematics and physics teacher in Nigeria. There is some evidence that autoregulatory responses to relatively large changes in ABP are similar to those resulting from small changes.
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