Abstract
Basal cell carcinoma (BCC) is the most frequently occurring form of all cancers. The cost of care for BCC is one of the highest for all cancers in the Medicare population in the United States. Activation of Hedgehog (Hh) signaling pathway appears to be a key driver of BCC development. Studies involving mouse models have provided evidence that activation of the glioma-associated oncogene (GLI) family of transcription factors is a key step in the initiation of the tumorigenic program leading to BCC. Activation of the Wnt pathway is also observed in BCCs. In addition, the Wnt signaling pathway has been shown to be required in Hh pathway-driven development of BCC in a mouse model. Cross-talks between Wnt and Hh pathways have been observed at different levels, yet the mechanisms of these cross-talks are not fully understood. In this review, we examine the mechanism of cross-talk between Wnt and Hh signaling in BCC development and its potential relevance for treatment. Recent studies have identified insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), a direct target of the Wnt/β-catenin signaling, as the factor that binds to GLI1 mRNA and upregulates its levels and activities. This mode of regulation of GLI1 appears important in BCC tumorigenesis and could be explored in the treatment of BCCs.
Highlights
Basal cell carcinoma (BCC) is the most common form of cancer, affecting more than two millionAmericans each year
insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is over-expressed in BCC and its expression positively correlates with the activation of both Wnt and Hh signaling pathways [27]
A cross-talk between Wnt and Hh signaling pathways appears to play a significant role in BCC development
Summary
Basal cell carcinoma (BCC) is the most common form of cancer, affecting more than two million. Immunocompromised patients have been reported to have a higher risk of developing BCC than the general population [9,10] and BCCs appear to show a more. Those drugs have been directed against smoothened (SMO), which is an important component of the Hh pathway This treatment method has been proven beneficial in many cases [23,24], the development of resistance remains a major concern as about. The Wnt/β-catenin signaling pathway is one of those pathways Investigating those interactions could be valuable in identifying better strategies in the treatment of advanced, inoperable and/or resistant. Wnt signaling pathways in BCC development, based on the literature covering the last two decades and the potential relevance of this cross-talk in the treatment of SMO inhibitors’ resistant BCCs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
