Abstract
Obesity is a multifactorial disease in which oxidative stress and inflammation play important roles. The aim of our study was to evaluate oxidative stress levels and inflammation markers in obese subjects vs. controls and to investigate the relationship between these values. We found increased levels of reactive oxygen species and inflammation markers (fibrinogen, ferritin, CRP, NLR) and decreased levels of antioxidants in obese subjects vs. controls.
Highlights
Crosstalk between Oxidative Stress and Inflammation in ObesityThe aim of our study was to evaluate oxidative stress levels and inflammation markers in obese subjects vs controls and to investigate the relationship between these values
Obesity is a multifactorial disease in which oxidative stress and inflammation play important roles
The main reactive oxygen species (ROS) involved in this process are the superoxide anion O2, the hydrogen peroxide H2O2 and the hydroxyl radical OH, whereas antioxidant enzymes, i.e. superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), uric acid, cofactors (e.g. NADPH), vitamin E, vitamin C, thioredoxin and glutathione (GSH) and trace metals counteract pro-oxidant effects of ROS
Summary
The aim of our study was to evaluate oxidative stress levels and inflammation markers in obese subjects vs controls and to investigate the relationship between these values. We found increased levels of reactive oxygen species and inflammation markers (fibrinogen, ferritin, CRP, NLR) and decreased levels of antioxidants in obese subjects vs controls. Recent studies have underlined that, in obese subjects, the adipose tissue dysfunction derives from the interplay between reactive oxygen species (ROS) signalling and inflammatory response pathways [1,2,3,4,5,6,7,8,9]. The aim of the study was to evaluate the levels of oxidative stress and inflammation markers in a group of patients stratified in different classes of obesity and to investigate the relationship between these variables. The study had the approval of the Ethics Committee of the University of Medicine and Pharmacy of Craiova (approval number: 40/27.03.2018)
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