Abstract
Crosstalk between Nitric Oxide and T helper cells
Highlights
Kalipada Pahan* and Susanta Mondal Department of Neurological sciences, Rush University Medical Center, Chicago, IL 60612, USA
We must remember while TGF-β and IL-6 are required for Th17 cells, TGF-β and IL-4 are required for the generation of Th9 cells [8]
The differentiation of naive CD4+ T cells into Th1, Th2, Th17, and Th9 is initiated by the engagement of their T cell receptor (TCR) and costimulatory molecules in the presence of specific cytokines produced by the innate immune cells, during any immune challenge, a gaseous lipophilic molecule called nitric oxide (NO) is often generated [10,11,12]
Summary
The inducible form (iNOS), expressed in various cell types including innate immune cells in response to wide variety of immunological cues [10,11], is regulated mainly at the transcriptional level and does not require calcium for its activity. We have demonstrated that NO is a key regulator of T-bet and GATA3 in neuroantigen-primed T cells [13]. Gemfibrozil, an FDA-approved lipid-lowering drug, suppresses the production of NO and the expression of iNOS in different cells [14,15,16].
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