Abstract
Cancer is a complex disease, and its study requires deep understanding of several biological processes and their regulation. It is an accepted fact that non-coding RNAs are vital components of the regulation and cross-talk among cancer-related signaling pathways that favor tumor aggressiveness and metastasis, such as neovascularization, angiogenesis, and vasculogenic mimicry. Both long non-coding RNAs (lncRNAs) and micro-RNAs (miRNAs) have been described as master regulators of cancer on their own; yet there is accumulating evidence that, besides regulating mRNA expression through independent mechanisms, these classes of non-coding RNAs interact with each other directly, fine-tuning the effects of their regulation. While still relatively scant, research on the lncRNA-miRNA-mRNA axis regulation is growing at a fast rate, it is only in the last 5 years, that lncRNA-miRNA interactions have been identified in tumor-related vascular processes. In this review, we summarize the current progress of research on the cross-talk between lncRNAs and miRNAs in the regulation of neovascularization, angiogenesis and vasculogenic mimicry.
Highlights
Cancer is a serious worldwide health problem that affects the health of all human cultures
We summarize the recent studies on the longnon-coding RNAs (lncRNAs)-miRNA-messenger RNAs (mRNA) crosstalk in order to provide insight into the complexity of the molecular mechanism that underlies neovascularization, angiogenesis, and vasculogenic mimicry
Neovascularization is a mechanism through which new blood vessels are made from preexistent ones, this process is lncRNA/miRNA/mRNA Crosstalk in Cancer coordinated by angiogenesis inductors and inhibitors following endothelial cell proliferation and migration [54]
Summary
Cancer is a serious worldwide health problem that affects the health of all human cultures. LncRNAs can act as molecular decoys, sequestering miRNAs, and inhibiting their interaction with their target messenger RNAs (mRNA) [6, 7]. We summarize the recent studies on the lncRNA-miRNA-mRNA crosstalk in order to provide insight into the complexity of the molecular mechanism that underlies neovascularization, angiogenesis, and vasculogenic mimicry.
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