Abstract
BackgroundPeroxisome proliferator-activated receptor gamma (PPARγ) has direct and indirect function in adipokines production process. We aimed to assess the possible influence of circulating PPARγ on relative risk of metabolic syndrome and also examine the association between circulating PPARγ and adipokines levels among obese subjects.MethodsA total of 96 obese subjects (body mass index (BMI) ≥30) were included in the current cross-sectional study. We assessed the body composition with the use of Body Composition Analyzer BC-418MA - Tanita. The MetS (metabolic syndrome) was defined based on the National Cholesterol Education Program Adult Treatment Panel III. All baseline blood samples were obtained following an overnight fasting. Serum concentrations of adipokines including Retinol binding protein 4 (RBP4), omentin-1, vaspin, progranulin, nesfatin-1 and circulating PPARγ was measured with the use of an enzyme-linked immunosorbent assay method. Statistical analyses were performed using software package used for statistical analysis (SPSS).ResultsWe found main association between circulating PPARγ and body composition in obese population. The risk of metabolic syndrome in subjects with higher concentration of PPARγ was 1.9 fold in compared with lower concentration of PPARγ after adjustment for age, sex and BMI. There was significant association between PPARγ and adipokines, specially nesfatin-1 and progranulin. Defined adipokines pattern among participants demonstrated the markedly higher concentration of vaspin, RBP4 and nesfatin-1 in participants with MetS compared to non-MetS subjects.ConclusionsIt appears all of studied adipokines might have association with PPARγ level and might simultaneously be involve in some common pathway to make susceptible obese subjects for MetS.
Highlights
Peroxisome proliferator-activated receptor gamma (PPARγ) has direct and indirect function in adipokines production process
As shown in this table we found significant differences on weight, BMI, fat mass, Free fat mass (FFM), trunk fat, TG, Resting Metabolic Rate (RMR) and waist circumference (WC)
Our results demonstrated no significant differences in fat percent, visceral fat, Fasting blood sugar (FBS), total cholesterol, HDL and LDL cholesterol, evaluated liver enzymes, hs-CRP, insulin, homeostasis model assessment (HOMA)-Insulin resistance (IR), BAI, and blood pressure (P > 0.05) between high and low levels of circulating PPARγ
Summary
Peroxisome proliferator-activated receptor gamma (PPARγ) has direct and indirect function in adipokines production process. We aimed to assess the possible influence of circulating PPARγ on relative risk of metabolic syndrome and examine the association between circulating PPARγ and adipokines levels among obese subjects. The possibility of having metabolic irregularities, including Metabolic Syndrome (MetS), develops with the level of obesity. Adipokines, with important endocrine functions expresses and secretes factors from adipose tissue [4]. Some of them including nesfatin-1 [5], retinol binding protein 4 (RBP4) [6], omentin-1 [7], vaspin [8], and progranulin [9], provide an extensive network of communication both within adipose tissue and are implicated directly in the pathologies associated with metabolic syndrome [10].
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