Abstract
Acupuncture has been used in China for thousands of years and concerned as a typical alternative medicine in inflammatory diseases nowadays. The nuclear factor-κB (NF-κB) transcription factor is an important regulator of inflammation. In this article, we discuss the role of acupuncture in NF-κB pathways and also present the acupoints selection, acupuncture administration, and related inflammation diseases and models from previous studies to bring readers close to a more complete understanding of the mechanisms between acupuncture and NF-κB in inflammatory diseases.
Highlights
Acupuncture is an oldest part of traditional Chinese medicine (TCM) with a history of more than three thousand years [1]
Most of the inflammatory responses caused by infection, inflammatory cytokines, and engagement of antigen receptors are associated with the activation of nuclear factor-κB (NF-κB) [7]
Results is review contains 8 articles which reveal the mechanisms on how acupuncture could regulate NF-κB, 9 articles which introduce the detail of acupuncture regulating NF-κB in inflammation response, and 22 articles which show evidence that acupuncture could ameliorate inflammatory diseases through NF-κB pathways
Summary
Acupuncture is an oldest part of traditional Chinese medicine (TCM) with a history of more than three thousand years [1]. The nuclear factor-κB (NF-κB) represents a family of inducible transcription factors [6]. TGFβ-activated kinase 1 could be activated in the intracellular signaling cascade and further activates a trimeric IκB kinase (IKK), which is composed of IKKα, β, and c. The IKK complex will degrade IκB family members with ubiquitination and phosphorylation, resulting in NF-κB release and nuclear translocation. The degradation of IκB, a key inhibition of NF-κB, is crucial for NF-κB activation and acts as a potential antiinflammatory target [8]
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