Abstract
Cross-reactive Antibodies against Avian Influenza Virus A (H5N1)
Highlights
Verma P, Brown JM, Nunez VH, Morey RE, Steigerwalt AG, Pellegrini GJ, et al Native valve endocarditis due to Gordonia polyisoprenivorans: case report and review of literature of bloodstream infections caused by Gordonia species
Unlike Octagam and Flebogamma, Human Immunoglobulin, pH 4.0, Intravenous immunoglobulin (IVIg) was likely derived from blood donors in China
Octagam and Immunoglobulin, pH 4.0, IVIg were more reactive with M2e of avian influenza virus (H5N1) (A/Thailand/SP-83/2004) than with other M2e peptides
Summary
IVIg contains pooled IgG from >1,000 blood donors and antibodies against various common human pathogens, including influenza virus A. We tested the efficacy of commercial preparations of IVIg (50 mg/mL of highly purified immunoglobulin) against homosubtypic influenza viruses A (H1N1 and H3N2) and their crossreactivity against avian influenza virus A (H5N1). We tested whether IVIg preparations would react and inhibit NA activity of human and avian influenza viruses by using a neuraminidase inhibition (NI) assay [2].
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