Abstract
Class II tetramer reagents were used to identify SARS-CoV-2-specific CD4+ T cell epitopes and study these epitope-specific T cells ex vivo. Dominant and subdominant epitopes were identified. Majority of epitopes identified have Funding Information: Funding was provided from NIH grants 3U19AI135817-04S1 (WWK), 1R21AI163999 (DMK) and NIH contract HHSN75N93019C00063 (DMK).Declaration of Interests: The authors declare no competing interests.Ethics Approval Statement: The study was approved by Benaroya Research Institute and University of Washington Institutional Review Boards and all blood samples were obtained with informed consent from the participants.
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