Cross-modality modulation of auditory midbrain processing of intensity information

Abstract

In nature, animals constantly receive a multitude of sensory stimuli, such as visual, auditory, and somatosensory. The integration across sensory modalities is advantageous for the precise processing of sensory inputs which is essential for animals to survival. Although some principles of cross-modality integration have been revealed by many studies, little insight has been gained into its functional potentials. In this study, the functional influence of cross-modality modulation on auditory processing of intensity information was investigated via recording neuronal activity in the auditory midbrain (i.e., inferior colliculus, IC) under the conditions of visual, auditory, and audiovisual stimuli, respectively. Results demonstrated that combined audiovisual stimuli either enhanced or suppressed the responses of IC neurons compared to auditory stimuli alone, even though the same visual stimuli alone induced no response. Audiovisual modulation appeared to be strongest when the combined audiovisual stimuli were located at the best auditory azimuth of neurons as well as when presented with intensity at near-threshold levels. Additionally, the rate-intensity function of IC neurons to auditory stimuli was expanded or compressed by audiovisual modulation, which was highly dependent on the minimal threshold (MT) of neurons. Lowering of the MT and greater audiovisual modulation for the neuron indicated an intensity-specific enhancement of auditory intensity sensitivity by cross-modality modulation. Overall, evidence suggests a potential functional role of cross-modality modulation in IC that serves to instruct adaptive plasticity to enhance the auditory perception of intensity information.