Abstract
A high shear mixer was utilized for the evaluation of pregelatinized and pregelatinized-crosslinked waxy-corn starches as binding agents in the wet granulation process. Lactose granules prepared with a high shear mixer showed a larger average size in comparison to granules prepared in a planetary mixer using the same amount of binding solution. The use of pregelatinized or pregelatinized-crosslinked starches as a paste provided larger and less friable granules than when the binder was added in the dry form. The high shear mixer produced granules with lower friability in comparison with those prepared in the planetary mixer. Granule size was influenced by the concentration of the binders while a difference in friability was not observed. No influence was observed for the experimental massing time on particle size distribution and on friability of the granules except when a paste of pregelatinized starch was used as a binder.
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