Abstract
To explore the potential role of polymers in the development of drug-delivery systems, this study investigated the use of β-cyclodextrin (β-CD), carboxymethyl cellulose (CMC), acrylic acid (AA) and N’ N’-methylenebis-acrylamide (MBA) in the synthesis of hydrogels for controlled drug delivery of acyclovir (ACV). Different proportions of β-CD, CMC, AA and MBA were blended with each other to fabricate hydrogels via free radical polymerization technique. Fourier transform infrared spectroscopy (FTIR) revealed successful grafting of components into the polymeric network. Thermal and morphological characterization confirmed the formation of thermodynamically stable hydrogels having porous structure. The pH-responsive behaviour of hydrogels has been documented by swelling dynamics and drug release behaviour in simulated gastrointestinal fluids. Drug release kinetics revealed controlled release behaviour of the antiviral drug acyclovir in developed polymeric network. Cross-linked β-cyclodextrin and carboxymethyl cellulose hydrogels can be used as promising candidates for the design and development of controlled drug-delivery systems.
Highlights
Hydrogels are hydrophilic polymeric network, with the ability to absorb large quantities of water and having physicochemical characteristics which make them suitable for use in human tissues[1]
The acrylic acid (AA) spectrum displayed prominent bands at 3016.79 cm-1, 1697.43 cm-1 and 1295.48 cm-1 attributed to -CH2 stretching vibrations, C = O stretching of carboxylic acid and C–C stretching vibrations, respectively. β-CD presented broad transmittance peak at 3303.33 cm-1, due to -OH stretching vibrations, asymmetric stretching vibrations of -CH were recorded at 2927.82 cm-1 whereas asymmetric stretching vibrations of C–O appeared at 1632.66 cm-1
The strong absorption bands at 1636.06cm−1 and 1448.48 cm−1 in the β-CD/carboxymethyl cellulose (CMC)-co-Poly(AA)hydrogel is an indication of the presence of carbonyl groups within the hydrogel framework
Summary
Hydrogels are hydrophilic polymeric network, with the ability to absorb large quantities of water and having physicochemical characteristics which make them suitable for use in human tissues[1]. They provide good platform for the development of polymeric drug delivery systems. Some drawbacks are still associated with hydrogels, when used as delivery system for drugs, such as decreased drug loading strength for hydrophobic drugs as well as less control over drug release mechanism[3] To overcome all these drawbacks, cyclodextrin based hydrogels have been developed. Cyclodextrin (CDs) based hydrogels have the benefits of enhanced swelling capability and augmented encapsulation efficiency for the loaded drug[4]
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