Abstract
BackgroundAs a noninvasive perfusion-weighted MRI technique, arterial spin-labeling (ASL) was becoming increasingly used to evaluate cerebral hemodynamics in many studies. The relation between ASL-MRI and crossed cerebellar diaschisis (CCD) was rarely discussed. In this study, the aim of our study was to assess the performance of ASL-MRI in the detection of crossed cerebellar diaschisis after stroke in compared with single-photon emission CT (SPECT).Results17 of 51(33.3%) patients revealed CCD phenomenon by the SPECT method. In CCD-positive group, CBFASL of ipsilateral cerebellar were significantly increased compared with contralateral cerebellar (p < 0.0001) while no significant differences (p = 0.063, > 0.001) in the CCD-negative group. Positive correlation was detected between admission National institute of health stroke scale (NIHSS) and asymmetry index of SPECT (AISPECT) (r = 0.351, p = 0.011), AIASL (r = 0.372, p = 0.007); infract volume and AISPECT (r = 0.443, p = 0.001), AIASL (r = 0.426, p = 0.002). Significant correlation was also found between cerebral blood flow of SPECT (CBFSPECT) and CBFASL, AISPECT and AIASL (r = 0.204, p = 0.04; r = 0.467, p = 0.001, respectively). Furthermore, the area under the receiver operating characteristic (ROC) curve value of AIASL was 0.829.ConclusionsCBF derived from ASL-MRI could be valuable for assessment of CCD in supratentorial stroke patients. Additionally, CCD was significantly associated with larger ischemic volume and higher initial NIHSS score.
Highlights
As a noninvasive perfusion-weighted MRI technique, arterial spin-labeling (ASL) was becoming increas‐ ingly used to evaluate cerebral hemodynamics in many studies
Higher A ISPECT and A IASL value was investigated in the crossed cerebellar diaschisis (CCD)-positive group compared to CCDnegative group respectively, and there was no significant difference between AISPECT and AIASL (p = 0.484)
There was a positive correlation between CBFASL and C BFSPECT, AIASL and A ISPECT, respectively, which implying that ASL might reflect the Cerebral blood flow (CBF) alteration in post-stroke CCD patients and be a novel imaging method for CCD detection
Summary
As a noninvasive perfusion-weighted MRI technique, arterial spin-labeling (ASL) was becoming increas‐ ingly used to evaluate cerebral hemodynamics in many studies. The relation between ASL-MRI and crossed cerebellar diaschisis (CCD) was rarely discussed. The aim of our study was to assess the performance of ASL-MRI in the detection of crossed cerebellar diaschisis after stroke in compared with single-photon emission CT (SPECT). With the development of MR techniques, several studies have been carried out to detect CCD by diffusion-tensor imaging (DTI) and perfusion-weighted MR imaging (PW-MRI). Dynamic susceptibility contrast perfusion weighted-imaging (DSC-PWI) was found to be able to identify CCD by various parameters but with a reduced sensitivity compared with PET/ SPECT [10]. Our previous study demonstrated that the fast diffusion coefficient derived from the intravoxel incoherent motion (IVIM) could be valuable for assessing CCD in supratentorial stroke [3]
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