Abstract
1. Simultaneous administration of 2 to 4 mg of d-2-Brom lysergic acid diethylamide (BOL-148) did not reduce the intensity of the reaction caused by 0.5 to 1.5mcg/kg of LSD-25. 2. Pre-treatment of 8 subjects with 3 mg of BOL-148 daily for two days caused statistically nonsignificant reductions in all aspects of the reaction induced by 1 mcg/kg of LSD-25. 3. Pre-treatment of 10 subjects with 3 mg of BOL-148 for five days resulted in statistically significant attenuation of all aspects of the LSD reaction that were measured. 4. The results are more compatible with the development of cross tolerance between BOL-148 and LSD-25 than they are with simple molecular competition between the two drugs.
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