Cross talk between adropin and possible metabolic syndrome disorders in experimental male albino rats

Abstract

This research is to study the relationship between adropin and possible metabolic syndrome disorders, also to assess the role of PPAR-α in these disorders in rats.  50 male rats were divided into 5 groups: I-Control group, II-Obese group, III-Obese diabetic group, IV-Adropin treated obese group, V-Adropin treated obese diabetic group. At the end, body weight, BMI, AC/TC ratio and lee index was measured, blood samples were collected for measuring glucose  ,  insulin, HbA1C  , HOMA-IR  ,  HOMA-β  ,  TC, TG, HDL-C ,  LDL-C,  atherogenic index ,  ALT, AST &  GGT. The liver was dissected for measuring PPARα expression, TNF-α, IL6 & iNOS.  High fat diet produced a significant increase in all anthropometric measures in group (II) and (III) compared to control group. After adropin administration they were significantly decreased. The serum blood glucose, insulin, HbA1c and HOMA-IR were significantly increased, while Β- cell function significantly decreased in group (II) and (III) compared to control, however after adropin administration they showed significant decrease while, HOMA-β was significantly decreased. Group (II) and (III) showed significant lipid profile deterioration compared to control group, after adropin treatment lipid profile was significantly improved.