Cross sectional study of p53 immunohistochemical expression of HER2-positive and negative breast cancer patients

Abstract

The current study included forty Iraqi female patients suffered from breast carcinoma were age varied from 34-75 years old, diagnosed through the period from 19 January 2019 to 7 April 2021. In present study used paraffin-embedded of female breast carcinoma sections have been confirmed histological diagnosis such as tumor size, differentiation degree and types of invasive breast cancers after reviewing all slides by specialist pathologists from different centers in AL-Najaf province. Cross sectional study of immunohistochemical expression of biomarker protein P53 (P53) positive and negative females with invasive breast cancers that have been conducted in Middle Euphrates Unit for Cancer Researches / University of Kufa . The highest percentage of P53 over expression was (12.5%) at age (50-59), while the lowest percentage found in age less than 40 years. The results obtained from the present study showed that there was significant difference (p<0.05) between P53 overexpression and patient age and according to histological type appeared of P53ve+ (27.5% in IDC and was (2.5%) in ILC, and P53ve+ which had significant difference (p<0.05) between P53ve+and histopathological type.