Abstract
BackgroundAs most data on hepatitis in resource-poor countries relate to urban communities, surveys in the rural environment are necessary to determine the ‘true’ prevalence of these viral infections. We undertook a survey to determine the prevalence of hepatitis B virus (HBV) infection in an apparently healthy rural population in the Central African Republic (CAR).MethodsThe cross-sectional study was based on dried blood spots (DBS) from 273 people recruited in four prefectures (Lobaye, Nana-Mambéré, Ouham and Ouaka). Eluates from DBS were tested with commercial ELISA kits to detect markers of HBV infection. DBS were directly used for DNA extraction, followed by PCR and genotyping based on preS/S gene sequences.ResultsThe overall prevalence of HBc antibodies was 27.1% (Lobaye 29%, Nana-Mambéré 28%, Ouaka 29% and Ouham 23%) and that of HBsAg was 10.6% (Lobaye 9%, Nana-Mambéré 9%, Ouaka 19% and Ouham 8%), with no statistically significant difference among the surveyed communities. Nineteen sequences obtained from 74 anti-HBc-positive patients all belonged to genotype E. Risk factor analysis of HBV infection pointed to sexual transmission of the virus.ConclusionThe prevalence of HBV is high in rural communities in the CAR and comparable to that observed in urban areas. In addition, genotype E is prevalent in these areas. These findings underline the importance of instituting a programme of active HBV surveillance and vaccination of the population.
Highlights
As most data on hepatitis in resource-poor countries relate to urban communities, surveys in the rural environment are necessary to determine the ‘true’ prevalence of these viral infections
Serology and geographical distribution of hepatitis B virus in the four prefectures In the tested population, comprising 173 (63.7%) females and 100 (36.6%) males aged 2–67 years, 74 people (27.1%) had anti-HBc antibodies, indicating that a high proportion of these rural populations had been exposed to HBV
The prevalence of HBV infection was higher in males than in females over 16 years of age (p = 0.03, Table 1)
Summary
As most data on hepatitis in resource-poor countries relate to urban communities, surveys in the rural environment are necessary to determine the ‘true’ prevalence of these viral infections. We undertook a survey to determine the prevalence of hepatitis B virus (HBV) infection in an apparently healthy rural population in the Central African Republic (CAR). Despite the availability of an effective vaccine, infection with hepatitis B virus (HBV) remains a major worldwide health problem: over 2 billion people have been in contact with the virus, and there are 400 million chronic carriers and 1 million deaths per year [1]. It is hyperendemic in sub-Saharan Africa and Asia [2,3,4,5]. In the Central African Republic (CAR), E is the prevalent genotype among HBVinfected patients, genotypes A1, D4 and a genotype E and D recombinant have been reported [10]
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