CROSS SECTIONAL STUDY OF COVID 19 CONVALESCENT PLASMA (COPLA) DONOR CHARACTERISTICS

Abstract

Background: Although many trials are currently investigating the safety and efcacy of convalescent plasma (CP) in critically ill COVID-19 patients, there is a paucity of ongoing and published studies evaluating the CP donors' side. In this regard, this study was aimed to nd out how SARS-CoV2 IgG antibodies are inuenced by demographic and clinical characteristics of donors such as age, sex, ABO/Rh blood group, disease severity, post recovery duration, ethnicity. After approval from the IEC Material & Methods: and consent from the study participants, the study was performed in Department of Pathology and Blood Bank of Sri Aurobindo Medical College and PG Institute, Indore (M.P) on a total of 785 COVID-19 recovered patients. A total Results: of 785 COVID-19 recovered patients were telephonically contacted for COPLA donation, out of which 103 donor candidates refused for the plasma donation while 82 donors were deferred by blood bank authorities for convalescent plasma donation. 600 donors successfully donated convalescent plasma in the present study. The most common reason for refusal of COPLA donation by the donors was Fear of reinfection (26.2%) followed by diabetes mellitus on insulin (16.5%). Whereas low antibody titre (53.7%) was the most common reason for COVID- 19 COPLA donor deferral in the present study. Majority were in age group 26-35 with higher prevalence of males. Donors' age and COVID-19 severity were positively associated with greater antibody responses. The awareness of CP donor characteristics, post-screening deferrals, and c Conclusion: orrelates of antibody values with age, gender, body weight, severity of COVID-19 disease and blood groups will help improve collection outcomes and give better preparedness for future recurrent waves due to evolution of more virulent SARS-CoV-2 strains and ll treatment gap till availability of more specic treatment.