Abstract
BackgroundDengue is caused by an arthropod-borne flavivirus. Infection can be either primary or secondary based on serology, with each stage of the disease characterized by specific serological conversion and antibody formation. Further study is needed to fully identify the factors associated with and predisposing to dengue infection. The objective of this study was to identify socio-demographic factors associated with the prevalence of dengue serotypes in Kassala State in the eastern part of Sudan in 2011.MethodsThis was a cross-sectional community-based study with 530 participants who were randomly selected through multi-stage cluster sampling. Dengue serotype prevalence was determined using capture Enzyme-linked immunosorbent assay (ELISA). ELISA IgG. A multivariate logistic regression model was designed to measure the strength of associations between socio-demographic factors and dengue serotype prevalence. All participants who tested negative for dengue were used as the statistical reference group.ResultsFrom this study, the prevalence of dengue in Kassala was estimated to be 9.4 % (95 % CI: 7.1–12.3). Lack of knowledge about dengue fever disease (OR 2.8, 95 % CI: 1.24–6.53) and a household density of more than 3 people per room (OR 2.1, 95 % CI: 1.06–4.09) were the most important factors associated with dengue infection among the study population.ConclusionsCommunity-oriented interventions are needed to modify existing social behaviors to reduce the risk of dengue in the eastern part of Sudan. Additional studies are also required in this field.
Highlights
Dengue is caused by an arthropod-borne flavivirus [1], and is currently endemic in several countries worldwide [2]
Primary dengue infection is defined as the first experience of a human host with dengue virus and can manifest in one of three clinical forms
People who had never heard about dengue, and households with a density of more than 3 people per room were found to be most likely to be dengue seropositive
Summary
Dengue is caused by an arthropod-borne flavivirus. Further study is needed to fully identify the factors associated with and predisposing to dengue infection. The objective of this study was to identify socio-demographic factors associated with the prevalence of dengue serotypes in Kassala State in the eastern part of Sudan in 2011. Dengue is caused by an arthropod-borne flavivirus [1], and is currently endemic in several countries worldwide [2]. Homotypic immunity (specific to the same serotype) is developed after infection with any one of the four serotypes, Improvements in laboratory tests allow dengue infections to be classified as either a primary or secondary infection, and either a recent or old infection. Other patients develop severe body pain and high fever, which is classic dengue fever. The remaining patients experience a severe form of dengue presenting
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