Abstract
Apolipoproteins exert a key role on glucose metabolism; however, scarce data have examined the relationship between apolipoproteins and glycated haemoglobin (HbA1c) in Chinese adults. This study determined the cross-sectional and longitudinal associations of serum Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB) and the ApoB/A1 ratio with HbA1c in Chinese adults. A total of 1448 subjects (584 men and 864 women) aged 54.8 years were included in a baseline survey, and the concentrations of Apo and HbA1c were measured. A total of 826 participants were followed up approximately once after 3.94 ± 0.62 years. In cross-sectional analysis, serum ApoA1 was inversely associated with HbA1c, while ApoB and the ApoB/A1 ratio were positively associated with HbA1c. After further adjusting for the potential covariates, a higher ApoA1 was associated with lower HbA1c (Quartile 4 [Q4] vs. Q1 = 5.673% vs. 5.796%, P-trend = 0.014). In contrast, positive association of ApoB concentration and the ApoB/A1 ratio with HbA1c level were showed (Q4 vs. Q1 = 5.805% vs. 5.589% for ApoB; Q4 vs. Q1 = 5.841% vs. 5.582% for ApoB/A1 ratio). The longitudinal results showed no significant associations of ApoA1, ApoB levels and the ApoB/A1 ratio with HbA1c changes (all P-trends > 0.05). Path analysis suggested that body mass index did not have mediating effect on Apo-HbA1c association. Our findings revealed that higher ApoA1, lower ApoB concentrations and the ApoB/A1 ratio were associated with lower HbA1c level in Chinese adults.
Highlights
Glycated haemoglobin (HbA1c), an integrated measure of circulating blood glucose levels during the previous 2 to 3 months, is considered as a gold standard for long period follow-up of blood glycemic c ontrol[1,2]
Previous study indicated that the levels of ApoA, Apolipoprotein B (ApoB), and lipoprotein were lower in Chinese adults than in Caucasians[15], scarce data is available for Chinese populations who differ from their Western counterparts in concentrations of lipoprotein[12,13,14]
To the best of our knowledge, the present study firstly identified the potential influence of Apolipoprotein A1 (ApoA1), ApoB concentrations and the ApoB/A1 ratio on HbA1c level in middle-aged and elderly Chinese populations
Summary
Glycated haemoglobin (HbA1c), an integrated measure of circulating blood glucose levels during the previous 2 to 3 months, is considered as a gold standard for long period follow-up of blood glycemic c ontrol[1,2]. In vitro and animal studies have demonstrated anti- or pro-diabetic effects of ApoA1 and ApoB9–11, observational studies aimed at exploring the association of ApoA1 and ApoB with HbA1c level found the inverse or null association with ApoA112–14 and positive association with ApoB13. These studies suggest that ApoA1 and ApoB may play important roles in maintaining circulating HbA1c level. The present study assessed the cross-sectional and longitudinal associations of ApoA1, ApoB levels and the ApoB/A1 ratio with HbA1c concentrations, and examined the mediating effects of body mass index (BMI) in the Apo-HbA1c association in middle-aged and elderly Chinese
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