Abstract
PurposeColorectal cancer (CRC) is the second most deadly cancer in the USA. Early detection can improve CRC outcomes, but recent national screening rates (62%) remain below the 80% goal set by the National Colorectal Cancer Roundtable. Multiple options are endorsed for average-risk CRC screening, including the multi-target stool DNA (mt-sDNA) test. We evaluated cross-sectional mt-sDNA test completion in a population of commercially and Medicare-insured patients.MethodsParticipants included individuals ages 50 years and older with commercial insurance or Medicare, with a valid mt-sDNA test shipped by Exact Sciences Laboratories LLC between January 1, 2018, and December 31, 2018 (n = 1,420,460). In 2020, we analyzed cross-sectional adherence, as the percent of successfully completed tests within 365 days of shipment date.ResultsOverall cross-sectional adherence was 66.8%. Adherence was 72.1% in participants with Traditional Medicare, 69.1% in participants with Medicare Advantage, and 61.9% in participants with commercial insurance. Adherence increased with age: 60.8% for ages 50–64, 71.3% for ages 65–75, and 74.7% for ages 76 + years. Participants with mt-sDNA tests ordered by gastroenterologists had a higher adherence rate (78.3%) than those with orders by primary care clinicians (67.2%). Geographically, adherence rates were highest among highly rural patients (70.8%) and ordering providers in the Pacific region (71.4%).ConclusionsData from this large, national sample of insured patients demonstrate high cross-sectional adherence with the mt-sDNA test, supporting its role as an accepted, noninvasive option for average-risk CRC screening. Attributes of mt-sDNA screening, including home-based convenience and accompanying navigation support, likely contributed to high completion rates.
Highlights
Colorectal cancer (CRC) is the second leading cause of cancer deaths and fourth most diagnosed cancer in the USA [1], representing an ongoing public health concern, with estimates of 149,500 incident and 52,980 fatal cases in 2021 [2]
The same National Health Interview Survey (NHIS) data showed that for those who completed screening, 4.1% used multi-target stool DNA (mt-sDNA), and use was consistent across demographic subgroups such as sex, age, and race/ethnicity, with no apparent
Descriptive statistics were used to describe the baseline characteristics of the study population overall and by insurance type
Summary
Colorectal cancer (CRC) is the second leading cause of cancer deaths and fourth most diagnosed cancer in the USA [1], representing an ongoing public health concern, with estimates of 149,500 incident and 52,980 fatal cases in 2021 [2]. Average-risk CRC screening can favorably impact the CRC public health burden by identifying patients with premalignant or localized malignant neoplasia for earlier, more effective intervention. National organizations such as the United States Preventive Services Task Force (USPSTF) in their. Between 2015 and 2018, estimated CRC screening rates increased overall by 4.2%, from 61.7 to 65.9% according to National Health Interview Survey data [6, 7]. The same National Health Interview Survey (NHIS) data showed that for those who completed screening, 4.1% used mt-sDNA, and use was consistent across demographic subgroups such as sex, age, and race/ethnicity, with no apparent
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
