Abstract
Two field isolates of Eimeria tenella were isolated on farms where continuous outbreaks of coccidiosis in broilers had occurred over several years. The isolates were repeatedly tested for their sensitivity to ionophorous polyether drugs in floor pen trials lasting 7 wk. Hybro cockerels were inoculated with 25 × 103 oocysts/chicken at the age of 23 to 24 days. Total mortality, mortality caused by coccidia, live weights, feed conversion ratios, number of oocysts in litter, and titers of circulating antibodies against E. tenella were followed. Tested isolates were not controlled by the monovalent polyether drugs monensin, narasin, and salinomycin, but maduramicin, which is a monovalent monoglycoside polyether, and the bivalent polyether lasalocid controlled them effectively.This study indicates that coccidia that lose their sensitivity to a monovalent polyether drug lose the sensitivity to other monovalent polyethers, also, but might yet be effectively controlled by drugs from other classes of polyether antibiotics. This supports the hypothesis that there are differences in the mechanisms of anticoccidial activity of different classes of polyether antibiotics.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
