Abstract
The sensitization to house dust mites (HDMs) and shrimps affects the development of hypersensitivity with an increase in age. Due to the cross-reactivity between shellfish and HDMs, HDMs were considered as the primary sensitizer for shellfish allergy. Thus, vegetarians might be sensitized to shrimp through the inadvertent inhalation of HDMs. Therefore, we assessed the prevalence of shrimp or mite allergy among different age groups and vegetarians. The serum specific-IgE (sIgE) level of HDMs and shrimp in 60 children/adolescence (un-adults), 30 adults, 30 elderly, and four vegetarian adults patients were measured. The sera with sIgE levels greater than 3.5 kUA/L were cross-reactivity examined. We found that HDMs induced higher sIgE than shrimp in un-adults. In contrast, shrimp-induced sIgE was higher in the adults and elderly patients. Moreover, adults were more frequently sensitized to shrimp and mite at the same time compared with the un-adult or elderly groups. The mite-Der p 10 not only displayed high cross-reactivity to the shrimp-Pen a 1 in all age groups and vegetarians but functioned as the major allergen to sensitize un-adults. Overall, the level of mite or shrimp sIgE is influenced by alterations in age, and vegetarians are at risk of shrimp sensitization via cross-reactivity between shrimp and mite.
Highlights
Increasing evidence demonstrates that the sensitization to indoor allergens is a causative factor for the development of airway hypersensitivity[1,2]
The results of the association between age and the mite sensitivity showed that the average levels of D. pteronyssinus sIgE were 11.9 kAU/L, 13.1 kAU/L, and 2.8 kAU/L in un-adults, adults and the elderly, respectively
The results of Basophil histamine release (BHR) assay showed that the percentages of histamine release were 69.27% in un-adults, 46.96% in un-adults, and 42.29% in elderly after stimulating with mite allergen (Fig. 2a)
Summary
Increasing evidence demonstrates that the sensitization to indoor allergens is a causative factor for the development of airway hypersensitivity[1,2]. It has been reported that with high sequence homology to shrimp tropomyosins, HDM allergens might be the primary sensitizer for shrimp allergy via cross-reactivity[13,14]. Previous studies indicated that the consumption of vegetables and fruits could increase antioxidants to combat inflammation, which induces anti-asthmatic effects[16,17]. The aim of this study was to investigate the prevalence and severity of shrimp or mite allergies among different age populations and vegetarians. We hope to clarify the allergen levels induced by mite and shrimp in different age groups and making changes in the dietary habits to prevent the immune response due to consumption of improper food
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