Cross-reactivity in Fish Allergy: A Double-blind, Placebo-Controlled Food Challenge Trial

Abstract

M Sorenson, A Kuehn, ENC Mills. J Allergy Clin Immunol. 2017;140(4):1170–1172 To evaluate the correlation between clinical reactivity to fish and immunoglobulin E reactivity (sensitization) to fish allergens. This study included 35 children and adolescents with physician-diagnosed fish allergy and sensitization to fish allergens. Subjects underwent a double-blind, placebo-controlled food challenge (DBPCFC) to cod ( n = 33), salmon ( n = 28), and mackerel ( n = 28). Levels of serum-specific immunoglobulin E (sIgE) to all 3 fish and to the fish allergens, parvalbumins and enolases and/or aldolases, were measured. On the DBPCFC, 24 (68%) subjects had …