Abstract
Background Nonsteroidal antiinflammatory drugs (NSAIDs) and antibiotics are widely used drugs and are the leading causes of adverse drug reaction (ADR), especially skin reactions. The photosensitizing effects of piroxicam are known for a long time and triggered by a photoproduct structurally similar to antigenic thiosalicylic acid present in the chemical formula of thimerosal and piroxicam. The thimerosal is a preservative used in topical products such as: antiseptics, eye drops, solutions for contact lens and vaccines. Patients sensitized to thimerosal may have photosensitivity reactions with the use of piroxicam by cross reaction to thiosalicylic acid.
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