Abstract
Cross metathesis of both anomers of C-allyl sialoside ( 3α/ 3β) with styrene catalyzed by the second generation Grubbs or Hoveyda-Grubbs catalysts gave the corresponding aryl derivatives ( 4α/ 4β) in virtually quantitative yields. The products were hydrogenated to model compounds 5α/ 5β. Similarly, reaction of the α-anomer 3α with galactose derivative 8 gave the olefin-linked disaccharide mimetic 9. Following hydrogenation and deprotection, the ethylene-bridged Neu5Acα(2→6)Gal analogue 11 could be obtained.
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