Abstract
AbstractA series of sodium alginate‐graft‐poly(acrylic acid) hydrogels (SA‐g‐pAA hydrogels) were synthesized with sodium alginate (SA) and acrylic acid (AA) in aqueous solution, ethylene glycol dimethacrylate (EGDMA) as a cross‐linker and ammonium peroxodisulfate (APS) as an initiator. Hydrogels were evaluated for thermal stability (TGA & DSC), revealing their higher strength toward thermal variation as compared to individual components. SEM micrographs show smooth and solid outer surface with a lack of porosity on it. FTIR results revealed the grafting reaction of AA on SA. Hydrogels were then evaluated for pH responsive behavior by equilibrium swelling ratio and swelling dynamics at low and high pH. Furthermore, these cross‐linked networks were also tested for the release of Loxoprofen sodium hydrate (LSH). Drug was loaded by diffusion method and showed pH‐dependent drug release characteristics. Korsmeyer–Peppas model is the best fit model to explain drug release from the cross‐linked network. Maximum swelling, drug loading, and release has been observed at pH 7.4. It is concluded that highly stable SA and AA based polymeric matrixes are developed. These polymeric matrixes have potential to be used as a carrier for controlled delivery of LSH.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
