Abstract
Owing to chitosan’s incredible biocompatibility and biodegradability, bioactive molecules loaded delivery systems based on this polymer have been widely studied for improved health benefits. In the present work, quercetin and ferulic acid encapsulated core-shell structure chitosan microparticles crosslinked with tripolyphosphate and sodium alginate have been fabricated using unique three fluid nozzle (3-FN) spray drying technique. Fluorescent molecules incorporated into the microparticles aided observation of core-shell structure formation. Compatibility studies, physicochemical properties, and free radical scavenging activity of microparticles were assessed. Microscopic analysis revealed core-shell structured, spherical shaped microparticles. Thermal and non-thermal method of evaluation confirmed the crosslinking, compatibility and encapsulation of bioactive molecules with the carrier materials. The dual bioactive molecules-loaded microparticles exhibited sustained release pattern (85–88%) for 24 h and had better free radical scavenging potency. Such cross-linked core-shell structured microparticle is a promising dual delivery system for encapsulating bioactive molecules with synergistic antioxidant activity.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Biological Macromolecules
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.