Abstract

AbstractA dual nickel‐/palladium‐catalyzed direct gem‐difluorovinylation of readily available aryl/vinyl triflates with substituted gem‐difluorovinyl tosylates is presented. This protocol affords various diaryldifluoroalkene, arylalkyldifluoroalkene and 1,1‐difluoro‐2‐substituted‐1,3‐dienes under mild reaction conditions with excellent functional group compatibility, and provides a potential pathway to the late‐stage functionalization of complex bioactive molecules.magnified image

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