Cross-cultural adaptation of the PAIR instrument: Pharmacotherapy Assessment in Chronic Renal Disease for application in Brazil

Alessandra Batista Marquito,Rogério Baumgratz De Paula,Hélady Sanders Pinheiro

doi:10.1590/1413-812320202510.35522018

Alessandra Batista Marquito, Rogério Baumgratz De Paula + Show 1 more

Open Access

https://doi.org/10.1590/1413-812320202510.35522018

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Abstract

Individuals suffering from chronic kidney disease (CKD) are often on multiple medications, which exposes them to drug-related problems (DRP). There are no available tools in Brazil to assess the pharmacotherapy and management of DRPs systematically in this population. The scope of this study was to perform a cross-cultural adaptation of PAIR criteria (Pharmacotherapy Assessment in Chronic Renal Disease) to Brazilian Portuguese. PAIR criteria consist of 50 DRP clinically significant items for CKD. The process of cross-cultural adaptation involved translation, synthesis, back-translation, and an analysis by an expert committee as well as a pre-test of the first draft document. A review committee consisting of 2 pharmacists and 2 nephrologists analyzed the semantic, linguistic, experiential, and conceptual equivalence between the original and translated versions. All items that obtained a score below 80% were reviewed. Word adjustments were made, as well as the exclusion of 6 DRP due to non-applicability to the Brazilian context. Thus, the final version of PAIR defined as "Avaliação da farmacoterapia na doença renal crônica" was translated and adapted into the Brazilian Portuguese language.

Highlights

Resumo Indivíduos com doença renal crônica (DRC) frequentemente utilizam polifarmácia o que os expõe ao risco de problemas relacionados a medicamentos (PRMs)
No Brasil, PRM é definido como um problema de saúde relacionado à farmacoterapia, que interfere ou pode interferir nos resultados terapêuticos e na qualidade de vida do usuário[9]
The patient is non-adherent to his diabetes treatment since he received more than 120% of the required quantity of drug over 90 consecutive days or less than 80% of the required quantity of drug over 90 consecutive days

Summary

The patient is receiving too high a dose of

5. O paciente está recebendo uma dose muito elevada de um antiviral (aciclovir, valaciclovir, fanciclovir), de acordo com as tabelas de ajuste de dose para doença renal. 6. O paciente está recebendo uma dose muito elevada de cefalosporina, de acordo com as tabelas de ajuste de dose para doença renal. 7. O paciente está recebendo uma dose muito elevada de inibidor da neuraminidase (oseltamivir, por exemplo), de acordo com as tabelas de ajuste de dose para doença renal. O paciente está recebendo uma dose muito elevada according to the dosage-adjustment tables for kidney de penicilina, de acordo com as tabelas de ajuste de disease. O paciente está recebendo uma dose muito elevada de uma sulfonamida, de acordo com as tabelas de ajuste de dose para doença renal

12. The patient is receiving too high a dose of a

23. The patient is non-adherent to his anemia

32. The patient is experiencing a drug interaction

Findings

41. The patient is experiencing an adverse reaction