Abstract
Cerebral infarction (CI) is the most common cerebrovascular disorder with high fatality and disability rates worldwide, and transient ischemic attack (TIA) is a warning of CI, and early diagnosis and intervention of TIA are very important for the prevention of CI. We screened a human aortic endothelial cell cDNA library using serum from TIA patients to obtain lysosomal-associated membrane protein 1 (LAMP1) antigen. Amplified luminescent proximity homogeneous assay-linked immunosorbentassay (AlphaLISA) revealed that the antibody levels against LAMP1 were significantly higher in patients with TIA or acute-phase CI (aCI) compared with healthy donors (HDs) (P < 0.01) by examined in three independent cohorts (77 and 158 in the TIA and acute aCI patient cohorts, respectively, and 122 in HD cohort used as normal control). Spearman correlation analysis demonstrated that LAMP1-Abs levels were positively correlated with cigarette smoking habit. The serum antibody levels against LAMP1 could potentially serve as a useful biomarker for early detection of TIA or predicting of the onset of CI.
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