Abstract

Two children in profound hepatic coma underwent cross circulation with chimpanzees following unsatisfactory response to conventional medical management and multiple exchange transfusions. One patient awoke dramatically five hours after completion of the procedure and remained conscious and alert altert for 20 days. Biochemical and coagulation derangements were transiently improved, but significant hepatic regeneration did not occur. Further investigation in providing temporary support for such patients with fulminant hepatic failure is necessary.

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