Abstract
Analysis of sequencing data for 143 blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae isolates from 13 European national collections and the public domain resulted in the identification of 15 previously undetected multi-country transmission clusters. For 10 clusters, cases had prior travel/hospitalisation history in countries outside of the European Union including Egypt, Iran, Morocco, Russia, Serbia, Tunisia and Turkey. These findings highlight the benefit of European whole genome sequencing-based surveillance and data sharing for control of antimicrobial resistance.
Highlights
Assistance Publique des Hôpitaux de Paris, Paris, France 7
An alert regarding an outbreak of carbapenem-resistant Klebsiella pneumoniae carrying bla NDM-1 and bla OXA48 carbapenemase-encoding genes was sent by Germany to European Union (EU)/European Economic
Since only limited whole genome sequencing (WGS) data on bla - NDM-1 and bla OXA-48-positive K. pneumoniae were available in the public domain, national public health reference or equivalent expert laboratories from EU/ EEA countries were invited to share WGS data from their national collections with the European Centre for Disease Prevention and Control (ECDC) to investigate the international dissemination of this epidemic strain
Summary
Cross-border spread of blaNDM-1- and blaOXA-48 positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019. For 10 clusters, cases had prior travel/hospitalisation history in countries outside of the European Union including Egypt, Iran, Morocco, Russia, Serbia, Tunisia and Turkey These findings highlight the benefit of European whole genome sequencing-based surveillance and data sharing for control of antimicrobial resistance. Since only limited whole genome sequencing (WGS) data on bla - NDM-1 and bla OXA-48-positive K. pneumoniae were available in the public domain, national public health reference or equivalent expert laboratories from EU/ EEA countries were invited to share WGS data from their national collections with the European Centre for Disease Prevention and Control (ECDC) to investigate the international dissemination of this epidemic strain. Several other clusters of genetically related bla - NDM-1 and bla OXA-48-positive K. pneumoniae unrelated to the German outbreak strain but affecting numerous EU/EEA countries were identified The aim of this follow-up investigation was to Figure 1 Mpoalyxmimourpmhilsikmeslihinoowdhotrleeegoenf obmlaeNsDfMr-o1 m- aEnUd/bElEaAOXnA-a4t8io-pnoaslitciovleleKctlieobnsise,l2la01p4n–e2u0m19on(nia =e i1s1o2l)a,teasnbdagseendoomnessinpgulbel-inculyclaevoatiildaeble on 23 November 2019 (n = 25). Characterise these clusters based on the integrated analysis of the WGS dataset on bla NDM-1 - and bla OXA48-positive K. pneumoniae submitted from 13 EU/EEA countries and additional epidemiological data
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