Abstract
BackgroundCronkhite-Canada Syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis and ectodermal abnormalities, the estimated incidence is about one per million. Recognizing and curing the disorder face great challenge.Case presentationThis report refers to a Chinese 52 year old man with gastrointestinal symptoms and ectodermal abnormalities. Gastrointestinal symptoms occurred without obvious cause, followed by ectodermal abnormalities after two months. In several hospitals, endoscopy examinations found numerous polypoid lesions in various sizes spreading over the stomach and the entire colon and rectum, histopathological examinations showed inflammatory and adenomatous polyp. In our hospital, both endoscopy and the contrast-enhanced computed tomography (CT) of small intestine showed gastrointestinal polyposis. Gastric antrum and the colon biopsy samples suggested hyperplastic and inflammatory polyp respectively. Endoscopic ultrasonography (EUS) suggested gastric wall thickening. Fujinnon intelligent color enhancement (FICE) revealed that the size of gastric glands pit varied, and vessels were visible. Confocal endoscope showed increased glandular epithelium layers. Magnifying narrow-band imaging endoscopy (ME-NBI) detected that pit pattern in the mucous of the polyp were regular and type III-IV of microvessels were seen. Biochemical investigations showed anemia, hypoalbuminemia and electrolyte disturbance. IgG, IgA and C3 decreased. Anti-ribosomal phosphoprotein is weak positive. The patient was given nutritional support treatment. Gstrointestinal symptoms and hyperpigmentation improved gradually.ConclusionThe patient was ever hospitalized in four hospitals and was diagnosed with CCS after 8 months of gastrointestinal symptoms. So when encountering the patient with gastrointestinal polyposis and ectodermal abnormalities, try to take CCS into consideration. Due to its low incidence, no standard therapy regimen has been established so far. However, nutritional support treatment is of great significance.
Highlights
Cronkhite-Canada Syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis and ectodermal abnormalities, the estimated incidence is about one per million
The patient was ever hospitalized in four hospitals and was diagnosed with CCS after 8 months of gastrointestinal symptoms
CCS is a rare non-inherited disease characterized by gastrointestinal polyposis and ectodermal abnormalities including hyperpigmentation, alopecia and onychodystrophy [1]
Summary
CCS is a rare disease, physician should have a profound understanding of the characteristics of gastrointestinal polyposis including heredity factor, onset age, parenteral manifestation and histopathology to try to avoid missed diagnosis and misdiagnosis. The name of ethics committee and reference number The Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology; IORG No: IORG0003571. Consent and permission The Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology (IORG No: IORG0003571) Voted at its meeting on 20/06/2015 to give final APPROVAL for the study Cronkhite-Canada syndrome: A rare case report and literature review which is conducted by Associate Prof. Takeuchi Y, Yoshikawa M, Tsukamoto N, et al Cronkhite-Canada syndrome with colon cancer, portal veinthrombosis, hightiter of antinuclear antibodies, and membranous glomerulonephritis. Cronkhite-Canada syndrome containing colon cancer and serrated adenoma lesions. Subtotal colectomy for severe protein-losing enteropathy associated with Cronkhite-Canada syndrome: a case report. LZ, RZ, OB and LC revised the manuscript to get final approval of the current submission. All authors read and approved the final manuscript
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
