Cronkhite-Canada Syndrome: A Case Report and Review of Literature

Kevin T Kao,Jitesh K Patel,Vijayamalini Pampati

doi:10.1155/2009/619378

Abstract

Cronkhite-Canada syndrome (CCS) is a rare syndrome first described in 1955. (1) Since then, 400 cases worldwide have been reported in the literature. The disease is characterized by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and abdominal pain. (2) The etiology is currently unknown, but an autoimmune process is suspected. The workup is based on history and physical followed by imaging and endoscopy with biopsy to confirm gastrointestinal polyposis. The goal of treatment focuses on symptomatic management of the patient and nutritional support.

Highlights

The workup is based on history and physical followed by imaging and endoscopy with biopsy to confirm gastrointestinal polyposis
Cronkhite-Canada syndrome (CCS) is a rare disease characterized by the presence of diffuse gastrointestinal polyposis, dystrophic changes in the fingernails, alopecia, cutaneous hyperpigmentation, diarrhea, weight loss, and abdominal pain
The estimated incidence of CCS is one per million based on the largest study performed to date [3]

Summary

Recommended by Yoshio Yamaoka

Cronkhite-Canada syndrome (CCS) is a rare syndrome first described in 1955. (1) Since 400 cases worldwide have been reported in the literature. The goal of treatment focuses on symptomatic management of the patient and nutritional support

Introduction

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Findings

Discussion