Abstract
Infectious Diseases Incorporated (IDI) is an infectious disease think-tank, established in 1973. Crohn’s disease (CD) is a chronic, recurrent disease of the gastrointestinal tract that has reached epidemic proportions within industrialized nations. CD is said to be without cure. Since 2003, therapeutic interventions have focused on disruption of the pro-inflammatory Th1 response against an unknown antigen. In 2015, the Hruska Postulate was introduced and, in so doing, explained how, in the absence of acquired immunity, newborn infection by Mycobacterium avium subspecies paratuberculosis could cause fixation of the immune system’s Th1 response against the organism. The Hruska Postulate was utilized to answer all the documented epidemiological facts embedded in the natural history of Crohn’s disease and, in particular, why breastfeeding confers protection against the future development of Crohn’s disease. It is Infectious Diseases Incorporated’s (IDI) stated opinion that Crohn’s disease is both preventable and curable if treated appropriately in its early stages.
Highlights
The overwhelming preponderance of retrospective studies have shown that breastfeeding confers protection against the future development of Crohn’s disease (CD)
In 2005, the University of Florida/Infectious Disease Incorporated collaborative team documented that Mycobacterium avium subspecies paratuberculosis (MAP) receptor sites lined the entire small bowel [7]
The Hruska postulate states that if a newborn lacking acquired immunity becomes infected with MAP, depending on the challenge dose and organismal virulence, the newborn’s inherent immune system can be so stressed as to become locked into its Th1 proinflammatory response
Summary
Hruska Postulate was utilized to answer all the documented epidemiological facts embedded in the natural history of Crohn’s disease and, in particular, why breastfeeding confers protection against the future development of Crohn’s disease. The natural history developed over the past 89 years explains what Crohn’s disease (CD) is. In 2008, the American Academy of Microbiology summary stated that “the association between MAP and CD (Crohn’s disease) is no longer in question.
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