Crohn’s Disease Is Associated With an Increased Prevalence of Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study Using Magnetic Resonance Proton Density Fat Fraction Mapping

Scott Mchenry,Yeshika Sharma,Ankita Tirath,Richard Tsai,Aaron Mintz,Tyler J Fraum,Amber Salter,Jeffrey D Browning,Avegail G Flores,Nicholas O Davidson,Kathryn J Fowler,Matthew A Ciorba,Parakkal Deepak

doi:10.1016/j.cgh.2019.02.045

Crohn’s Disease Is Associated With an Increased Prevalence of Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study Using Magnetic Resonance Proton Density Fat Fraction Mapping

Scott Mchenry, Yeshika Sharma + Show 11 more

Open Access

https://doi.org/10.1016/j.cgh.2019.02.045

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Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association	Publication Date: Mar 12, 2019
Citations: 19

Affiliation: Washington University in St. Louis, University of Washington, University of Cincinnati, The University of Texas Southwestern Medical Center, University of California, San Diego

#Proton Density Fat Fraction Mapping #Nonalcoholic Fatty Liver Disease + Show 8 more

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Abstract

Nonalcoholic fatty liver disease (NAFLD) commonly coexists with Crohn's disease (CD); however, it remains unclear if it is more prevalent than would be expected as ultrasound surveys of CD patients report a very wide range of prevalence (9%-40%).1-3 To address this uncertainty, we performed a prospective, cross-sectional survey of NAFLD in CD patients by generating magnetic resonance proton density fat fraction (MR-PDFF) maps as compared with 2 control populations. MR-PDFF provides a quantitative, sensitive and specific (97% and 100%, respectively) radiographic surrogate for liver fat.4.

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