Abstract
Three elderly sisters presented with symptomatic Crohn's disease. All had ileocolic involvement, and granulomatous inflammation was documented in endoscopic biopsies or surgically resected intestinal specimens. The present report documents the unusual occurrence of very late phenotypical expression of familial ileocolic Crohn's disease. The observations presented here reflect a possible gene-based predisposition to Crohn's disease or, alternatively, disease clustering related to a commonly shared environmental factor.
Highlights
Three elderly sisters presented with symptomatic Crohn’s disease
Symptoms persisted despite alternate-day prednisone; as a result, an ileocolic resection was performed along with a cholecystectomy for gallstones
In July 1980, she was readmitted for recurrent abdominal pain, diarrhea and perianal pain
Summary
Crohn’s disease defined in three elderly sisters. Three elderly sisters presented with symptomatic Crohn’s disease. Granulomatous inflammation was documented in endoscopic biopsies or surgically resected intestinal specimens. The present report documents the unusual occurrence of very late phenotypical expression of familial ileocolic Crohn’s disease. The observations presented here reflect a possible gene-based predisposition to Crohn’s disease or, alternatively, disease clustering related to a commonly shared environmental factor
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