Abstract
Crocodiles are remarkable animals that have the ability to endure extremely harsh conditions and can survive up to a 100 years while being exposed to noxious agents that are detrimental to Homo sapiens. Besides their immunity, we postulate that the microbial gut flora of crocodiles may produce substances with protective effects. In this study, we isolated and characterized selected bacteria colonizing the gastrointestinal tract of Crocodylus porosus and demonstrated their inhibitory effects against three different cancerous cell lineages. Using liquid chromatography-mass spectrometry, several molecules were identified. For the first time, we report partial analyses of crocodile’s gut bacterial molecules.
Highlights
Among many other possible sources, we investigated the effect of metabolites from an under-investigated source such as crocodile gut
The overall aim of the study was to determine whether the selected gut bacteria of crocodile may be a repertoire of potential novel molecules
Most prior studies conducted on the microbiota of crocodile involved characterization of bacteria isolated from cloacal swabs [18,19]
Summary
Crocodilians and birds are the only extant archosaurs, having survived the catastrophic. Homo sapiens is just one species amid millions of others and we are a moderately new addition to this planet. Crocodilians in sanctuaries and farms are normally exposed to radiation, heavy metals, diet of rotten meat, pollutants, etc. Even with exposure to stressful environments and carcinogenic materials, these species thrive under conditions that are considered unfavorable to Homo sapiens. The basis of their endurance is not clear and we speculated that such species may have mechanisms to protect themselves from noxious agents and to endure such longevity [7]
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