Abstract
Genome editing enables manipulation of nucleic acids by introducing DNA cuts at specific genomic sites. The most exciting genome editing machinery is CRISPR-Cas9, a “molecular scissor” that is bearing innovative discoveries across the field of Life Sciences. CRISPR-Cas9 has been the object of intensive investigations, involving structural, biophysical and computational methods. Yet, the catalytic mechanism of DNA cleavage, which forms the ground for genome editing power of CRISPR-Cas9, has remained largely elusive, potentially limiting design improvements and its harnessing in biomedical applications.
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