Critical review of bariatric surgical outcomes in patients with Prader-Willi syndrome and other hyperphagic disorders

Abstract

Brief Summary: This review analyzes the outcomes after bariatric procedures among patients with Prader-Willi syndrome (PWS), melanocortin 4 receptor (MC4R) mutations, Bardet-Biedl syndrome (BBS), and hypothalamic obesity (HO). The benefit of bariatric surgery in patients with hyperphagic disorders is only temporary or even absent, indicating the strength of perturbation in the regulation of energy homoeostasis in these patients leading to an elevated body weight set-point [9].