Abstract
Critical periods of adaptation occur when ecologically determined critical periods, caused by a high intensity of environmental factors, and critical stages of ontogenesis, predetermining a low level of resistance to these factors, coincide. We present a qualitative synthesis of the literature on human disadaptation caused by selected environmental factors through the mechanism of environmentally related oxidative stress (EROS) linked to epigenesis, mutagenesis, and oncogenesis. As an indicator of deleterious effects of exposure to environmental factors during critical periods we considered leukemia, lymphoms, tumors of the central nervous system, embryonic tumors and soft tissue sarcomas among children. We present a method for calculating the critical stages of ontogenesis and their sensitivity to smoke and solar activity time series analysis on the associations between environmental factors and the incidence of neoplasms with estimation of time lag between the exposures and the outcomes. Moreover, we propose a set of measures to reduce the negative impact of the environmental factors during critical periods of human ontogenesis.
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